Toxicological, nutritional and genetic aspects of wheat proteins

Bedetti C., Bozzini A., Pocchiari F., Silano V., Vittozzi L. (1973) Biochemical Studies on the Phylogenesis of alpha-amylase protein inhibitors from wheat seed. In: Proceedings of the Symposium on Genetics and Breeding of Durum Wheat. Bari (Italy) May 14-18, 1973 (Scarascia-Mugnozza G. Ed.) p. 71-77 Li-brary of the Faculty of Agriculture, University of Bari,Italy.

Bedetti C., Bozzini A., Silano V., Vittozzi L. (1974) Amylase protein inhibitors and the role of Aegilops species in the po-lyploid wheat speciation. Biochim. Biophys. Acta 362, 299-305

Vittozzi L., Morisi G., Silano V. (1976) Continuous automated as-say of alpha-amylase inhibitors. J. Sci. Food Agric. 27, 449-454

Vittozzi L., Silano V. (1976) The phylogenesis of protein alpha-amylase inhibitors from wheat seed and the speciation of poly-ploid wheats. Theoret. Appl. Genet. 48, 279-284

Pace V., Parlamenti R., Ur Rab A.,Silano V., Vittozzi L. (1978) Protein amylase inhibitors from wheat flour. Cereal Chem. 55, 244-257

Silano V., Vittozzi L., Ade P. (1978) Aspetti biochimici del mi-glioramento nutrizionale e tecnologico del frumento duro. Mo-nografie di Genetica Agraria. Vol. 3 (Edizioni dell'Istituto Sperimentale per la Cerealicoltura).

Ramundo Orlando A., Ade P., Di Maggio D., Fanelli C., Vittozzi L. (1983) The purification of a novel amylase from Bacillus sub-tilis and its inhibition by wheat proteins. Biochem. J. 209, 561-265

Vittozzi L., De Angelis G., Silano V. (1987) Solvent perturbation spectra of yellow mealworm alpha-amyalse and of wheat protein inhibitors. Int. J. Biochem. 19, 281-284.
 

Regulations and strategies for the control of the ecotoxicological effects of chemicals

Ade  P.,  Buonocore  V., Fanelli  R.,  Scoppa  P., Silano  V.,  Vittozzi L., (1980) Aspetti legislativi della prevenzione i-gienico-sanitaria  dell'ambiente dai rischi derivanti dalla produzione, commercializzazione ed uso dei prodotti chimici. In:  Atti  del  Seminario  sulla Ecotossicologia, CNR, Roma, 1980, AC/1/91, pp. 109-120.

Ade  P., Buonocore V., Fanelli R.,  Scoppa P.,  Silano  V.,  Vittozzi L. (1980) Le indagini metaboliche   negli   studi   di ecotossicologia.    In:   Atti  del  seminario sull'ecotossi-cologia, CNR, Roma, 1980, AC/1/92, pp. 121-148.

Ade P., Buonocore V.,  Fanelli  R., Scoppa  P.,  Silano V., Vittozzi L. (1980) Metodologie per lo studio del destino dei  prodotti chimici  nell'ambiente.  In: Atti  del  seminario sull'ecotossicologia, CNR, Roma, 1980. AC/1/93, pp. 149-169.

Ade P., Buonocore V., Fanelli  R., Scoppa  P.,  Silano V., Vittozzi L. (1980) Priorità   fra   i   composti   da   sottopor-re  a investigazioni  di ecotossicologia e sintesi delle linee  di ricerca  a breve termine. In: Atti  del  seminario sull'e-cotossicologia, CNR, Roma, 1980, AC/1/94, p. 171-187.

Silano  V., Vittozzi L. (1980) Metabolismo  di sostanze tossiche.  In:   Mutagenesi   ambientale:   metodiche  di analisi. Vol.II - test in vivo. CNR, Roma, 1980, AC/1/97, pp. 37-58.
 
 

Mechanisms of toxicity of polihalogenated chemicals
 

Testai, E. and Vittozzi L.  (1984) Different pathways of chloro-form metabolism. Arch.  Toxicol. Suppl.7, 278-281.

Vittozzi L., Testai E., Ade P., Gramenzi F. (1984) Effetti di i-drocarburi alifatici polialogenati sulla funzionalità di fra-zioni subcellulari epatiche. In: Atti del Convegno su "Il ri-schio genotossico: validità e prospettive nella ricerca attua-le". Follonica (Italy) April 11-14, 1984. pp.118-122.

Testai, E. and Vittozzi L.  (1986) Biochemical alterations eli-cited in rat liver microsomes by oxidation and reduction pro-ducts of chloroform metabolism. Chem.  Biol.  Interact. 59, 157-171.

Testai, E., Gramenzi, F., Di Marzio, S. and Vittozzi L.  (1987) Oxidative and reductive biotransformation of chloroform in mouse liver microsomes. Arch.  Toxicol. Suppl.11, 42-44.

Vittozzi L. and Nastainczyk, W.  (1987) Binding of reactive me-tabolites of CCl4 to specific microsomal proteins. Biochem.  Pharmacol. 36, 1401-1406.

Fiorucci, L., Monti, A., Testai, E., Ade, P. and Vittozzi L.  (1988) In vitro effects of polyhalogenated hydrocarbons on li-ver mitochondria respiration and microsomal cytochrome P-450. Drug Chem.  Toxicol. 11, 387-403.

Testai, E., Di Marzio, S. and Vittozzi L.  (1990) Multiple acti-vation of chloroform in hepatic microsomes from uninduced B6C3F1 mice. Toxicol.  Appl.  Pharmacol. 104, 496-503.

Vittozzi L., Testai, E. and De Biasi, A.  (1991) Multiple acti-vation of chloroform: a comparison between man and experimen-tal animals. In: Biological Reactive Intermediates (Eds. C.M. Witmer et al.)  Vol. IV, pp.665-667. Plenum Press, NY

Testai, E., Keizer, J., Pacifici, G.M. and Vittozzi L.  (1991) Chloroform bioactivation by microsomes from colonic and ileal mucosa of rat and man. Toxicol.  Lett. 57, 19-27.

Testai E., Gemma S., Vittozzi L. (1992) Bioactivation of chloro-form in hepatic microsomes from rodent strains susceptible or resistant to CHCl3 carcinogenicity. Toxicol. Appl. Pharmacol. 114, 197-203.

De Biasi A.,Sbraccia M., Keizer J., Testai E., and Vittozzi L. (1992) The regioselective binding of CHCl3 reactive interme-diates to microsomal phospholipids. Chem.-Biol. Interact. 85, 229-242.

Vittozzi L., Testai E. (1993) Chloroform. In: Handbook of hazar-dous materials. (M. Corn Ed.) Academic Press Inc. pag.119-125.

Testai E., Gemma S., Gervasi P.G., Menicagli S., and Vittozzi L. (1994) Effect of ethanol on CHCl3 metabolism in hepatic microsomes from Osborne-Mendel rats. Environ. Health Perpect. 102, Suppl. 9, 25-30.

Gemma S., Sbraccia M., Testai E., and Vittozzi L. (1994) In vivo production of different chloroform metabolites: effect of phe-nobarbital and buthionine Sulfoximine pretreatment. En-viron. Health Perspect. 102, Suppl. 9, 45-47.

Ade P., Guastadisegni C., Testai E. and Vittozzi L. (1994) Multi-ple activation of chloroform in kidney microsomes from male and female DBA/2J mice. J. Biochem. Toxicol., 9, 289-295.

De Curtis V., Gemma S., Sbraccia M., Testai E. and Vittozzi L. (1994) The contribution of electrophilic and radicalic inter-mediates to phospholipid adducts formed by halomethanes in vi-vo. J. Biochem. Toxicol., 9, 305-310.

WHO- IPCS (1994) Chloroform. Env. Health Criteria 163 (Vittozzi L.: Vice-Chairman of the Task Group)

Guastadisegni C., Ade P., Vittozzi L. (1995) Modulation of chloroform metabolism in freshly isolated rat hepatocytes. J. Exp. Clin. Cancer Res. 14 Supplement 71-73.

Testai, E., Di Marzio, S., Di Domenico, A., Piccardi, A. and Vittozzi L. (1995). An in vitro investigation of the reductive metabolites of chloroform. Arch.Toxicol. 70,83-88.

Gemma, S., Faccioli, S., Chieco, P., Sbraccia, M., Testai, E. and Vittozzi L. (1996). In vivo CHCl3 bioactivation, toxicokinetics, toxicity and induced compensatory cell proliferation in B6C3F1 male mice. Toxicol.Appl.Pharmacol. 141, 394-402

Gemma, S., Ade, P., Sbraccia, M., Testai, E. and Vittozzi L. (1996). In vitro quantitative determination of phospholipid adducts of chloroform intermediates in hepatic and renal microsomes from different rodent strains. Environ.Toxicol.Pharmacol. 2, 233-242

Guastadisegni, C., Balduzzi, M. and Vittozzi L. (1996). Preliminary characterization of phospholipid adducts formed by [14C]-CHCl3 reactive intermediates in hepatocyte suspensions. J. Biochem. Toxicol. 11, 21-25.

Testai, E., De Curtis, V., Gemma, S., Fabrizi, L., Gervasi, P.G. and Vittozzi L. (1996). The role of different cytochrome P-450 isoforms in in vitro chloroform metabolism. J. Biochem. Toxicol. 11, 305-312.

Guastadisegni C., Guidoni L., Balduzzi M., Viti V., Di Consiglio E., and Vittozzi L. (1998). Characterization of a phospholipid adduct formed in Sprague Dawley rats by chloroform metabolism: NMR studies. J. Biochem. Toxicol. 12, 93-102.

Vittozzi, L., Gemma S., Sbraccia M., and Testai E. (2000). Comparative characterization of CHCl3 metabolism and toxicokinetics in rodent strains differently susceptible to chloroform-induced carcinogenicity. Environ. Toxicol. Pharmacol. 8, 103-110.

Di Consiglio E., De Angelis G., Testai E., Vittozzi L. (2000) Correlation of a specific mitochondrial phospholipid-phosgene adduct with chloroform acute toxicity. Toxicology, (accepted for publication)
 
 

Metabolism and mechanisms of toxicity of chemicals in fish
 

Ade, P., Banchelli-Soldaini, M.G., Castelli, M.G., Chiesara, E., Clementi, F., Fanelli, R., Funari, E., Ignesti, G., Marabini, A., Oronesu, M., Palmero, S., Pirisino, R., Ramundo Orlando, A., Rizzi, R., Silano, V., Viarengo, A. and Vittozzi L.  (1984) Biochemical and  morphological comparison of microsomal preparations from rat, quail, trout, mussel and water flea. E-cotoxicol.  Environ.  Safety 8, 423-435.

Funari, E., Zoppini, A., Verdina, A., De Angelis, G. and Vittozzi L.  (1987) Xenobiotic-Metabolizing Enzyme Systems in Test Fish I. Comparative Studies of Liver Microsomal Monooxygena-ses. Ecotoxicol.  Environ.  Safety 13, 24-31.

Verdina, A., De Angelis, G., Funari, E., Testai, E. and Vittozzi L.  (1987) Xenobiotic-metabolizing enzyme systems in test fish. - II. The ethylmorphine N-demethylase activity of guppy (Poecilia reticulata) liver. Comp.  Biochem.  Physiol. 88B, 619-624.

Donnarumma, L., De Angelis, G., Gramenzi, F. and Vittozzi L.  (1988) Xenobiotic Metabolizing Enzyme Systems in Test Fish III. Comparative Studies of Liver Cytosolic Glutathione S-Transferases. Ecotoxicol.  Environ.  Safety 16, 180-186.

Keizer, J., D'Agostino, G. and Vittozzi L.  (1991) The importan-ce of biotransformation in the toxicity of xenobiotics to fish: I. Toxicity and bioaccumulation of Diazinon in guppy (Poecilia reticulata) and zebra fish (Brachidanio rerio). A-quatic Toxicology 21, 239-254.

La Rocca C., Di Domenico A., and Vittozzi L. (1991) Chemiobioki-netic study in freshwater fish exposed to lindane: uptake and excretion phase rate constants and bioconcentration factors. Int. J. Environm. Health Research 1, 103-116.

Vittozzi L. and De Angelis, G.  (1991) A critical review of com-parative acute toxicity data on freshwater fish. Aquatic Toxi-cology 19, 167-204.

Soldano, S., Gramenzi, F., Cirianni, M. and Vittozzi L.  (1992) Xenobiotic-metabolizing enzyme systems in test fish: IV. Com-parative studies of microsomal and cytosolic hydrolases. Comp.  Biochem.  Physiol. 101C, 117-123.

Keizer J., D'Agostino G., Nagel R., Gramenzi F., and Vittozzi L.(1993) Comparative diazinon toxicity in guppy and zebra fish: different role of oxidative metabolism. Environ. Toxi-col. Chem., 12, 1243-1250.

Iannelli M.A., Marcucci I. and Vittozzi L. (1994) Xenobiotic-meta-bolizing enzyme systems in test fish: V. Comparative studies of liver microsomal glucuronyl-transferase, Ecotoxicol. Envi-ronm. Safety, 28, 172-180.

Vittozzi L., Keizer J., Iannelli M.A., Soldano S. (1994) Comparative apsects of the metabolism and toxicity of xenobiotics in fish. In: Contaminants in the Environment pg. 75-79. Lewis Publi-shers/CRC Press.

Keizer J., D'Agostino G., Nagel R., Volpe T., Gnemi P. and Vittozzi L. (1995) Enzymological differences of AChE and diazinon metabolism: correlation of in vitro data with the selective toxicity of diazinon to fish species. Sci Tot. Environ. 171, 213-220.

Gallo D., Merendino A., Keizer J., Vittozzi L. (1995) Acute toxicity of two carbamates to the guppy (Poecilia reticulata) and the zebrafish (Brachidanio rerio). Sci Tot. Environ. 171, 131-136.

Vittozzi L., Fabrizi L., Di Consiglio E., Testai E. (1999) Mechanistic aspects of organophosphorothionate toxicity in fish and mammals. Environm. Int. Accettato per la pubblicazione
 

Other subjects

Ade P.,Confaloni A., Filesi C., Ramundo Orlando A., Serlupi Cre-scenzi G., Vittozzi L. (1982) Nutritional studies of n-alkane grown yeasts. Effect on activities of microsomal enzymes. Nutr. Reports Int. 25, 753-

Petrucci F., Alimonti A., Delle Femmine P., Di Ottavio A., Vittozzi L., Funari E., Shukla S. K., Caroli S. (1985) An inve-stigation of Gallium uptake in normal and malignant tissues by atomic spectroscopy techniques. In: Atti del XXI seminario spettochimico AIM e della V riunione italo-francese di spet-trometria atomica. Frascati 4-7 Giugno 1985. Vol. 1, pp. D9-

Silano V., Stammati A.L., Vittozzi L., Zucco F. (1986) Possibili-ties for in vitro methods. In: Chemicals testing and animal welfare. Proc. Int. Seminar on the prospects of future chemi-cals testing with special regard to the use of animals. OECD, pp. 152-

Baldini M., Coni E., Vittozzi L. (1987) Significato sanitario della contaminazione da Cadmio negli alimenti [Health significance of the Cadmium contamination of food]. Biologia Oggi 3-4, 91-

Di Folco S., Stammati A.L., Vittozzi L. and Zucco F. (1990) Studies of cytotoxicity and metabolic competence with the rat in-testinal cell line IEC-17. Drug Chem. Toxicol., 13, 221-228.

Vittozzi L. (1991) Salute ed inquinamento ambientale dell'aria [Human health and air pollution]. Condizionamento dell'aria 7, 943-949.

Vittozzi L. (1992) Toxicology of nitrates and nitrites. Food Ad-ditives and Contaminants 9 (5), 579-585.

Vittozzi L. (1994) Application of metabolic studies to the eva-luation of the toxicity of chemicals to man. In: Contaminants in the Environment pg. 69-73. Lewis Publishers/CRC Press.

Vittozzi L. (1994) Metabolic studies and the toxicological eva-luation of chemicals. Eur Bulletin of Drug Research  3 (3), 124-130.

Vittozzi L. (1995) Metabolic studies and the toxicological eva-luation of chemicals. Toxicol. Rev. (Moskow) 1 , 49-54.(in Russian)

Essers A. J., Alink G. M., Speijers G. J. A., Alexander J., Bouwmeister P.-J., van den Brandt P. A., Ciere S., Gry J., Herrman J., Kuiper H. A., Mortby E., Renwik A. G., Shrimpton D. H., Vainio H., Vittozzi L., Koeman J. H. (1998) Food plant toxicants and safety. Risk assessment and regulation of inherent toxicants in plant foods. Environ. Toxicol. Pharmacol. 5, 155-172