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Drugs & Diving: Do They Mix?

The dive doc's commonsense guide to everyday medications and how they can affect you under water.

By Samuel Shelanski, M.D.


When it comes to packing for a dive vacation, most of us put more thought into what goes in our gear bag than what goes in the toiletries kit. But the medications you take can have serious effects on your diving.

While the effects of depth and pressure have not been specifically studied for many common prescription and over-the-counter medications, a basic understanding of what's in your pill case and a few commonsense rules can help avoid complications.


Drugs and Diving: The Rules

Common Medications: Are They Safe?


Drugs and Diving: The Rules

Rule #1: Consult your doctor.

The following classes of drugs are discussed in terms of common effects and whether there is anything in their chemical makeup that makes them unsafe to use while diving. However, each person's situation is different. Many drugs are prescribed for a variety of conditions and some medical conditions may preclude safe diving even if the medication does not. If you take any medication on a regular basis, be sure your doctor has cleared you to dive with both your condition and the drug.

Rule #2: Know exactly what you're taking.

Different companies often market the same drug under several brand names, and in many cases, a pill may be a combination of several drugs. Medicines are referred to here by their generic names with the brand name in parentheses. Before you mix any medication and diving, read the ingredients label closely and consult your physician if you have any doubts.

Rule #3: Medicines affect each person differently.

Never take a new drug for the first time right before diving. And if any medication makes you feel antsy, nervous, sleepy or disoriented, don't dive while taking it, even if it's considered safe.

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Common Medications: Are They Safe?


Decongestants

What are they? Decongestants shrink inflamed nasal and sinus membranes, opening these passages so that air can pass more easily. Because they can make equalizing easier, decongestants are commonly used by divers. Pseudoephedrine (Sudafed), phenylpropanolamine, oxymetazoline (Afrin) and phenylephrine (Neo-Synephrine) are commonly used decongestants, sometimes combined with an antihistamine and pain relievers in cold or sinus preparation. Steroids are also becoming more popular to relieve the symptoms of stuffy nose and sinuses that are caused by allergies. Steroid inhalers such as triamcinolone (Nasacort) are also available over-the-counter.

Potential downside: While generally well-tolerated, some people find that these medications may make them agitated, nervous, or make them feel as though their heart is racing. Reverse squeeze can occur if the drug wears off during the dive.

Safe for diving? Yes. Make sure that you have used the medication on land before using it while diving. Use of long-acting preparations helps to minimize the risk of the medication wearing off mid-dive.

Common brand names: Sudafed, Afrin, Nasacort.

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Antihistamines

What are they? Antihistamines, often combined with other drugs in cold or sinus preparations, combat the symptoms of allergies. Common over-the-counter antihistamines include diphenhydramine (Benadryl), clemastine fumarate, chlorpheniramine maleate and brompheniramine maleate. Most are also available in prescription strength doses or in combination with other medicines. Other antihistamines, including astemizole (Hismanal), loratadine (Claritin), and cetirizine (Zyrtec), are available by prescription only.

Potential downside: Most over-the-counter antihistamines cause drowsiness and can interfere with your ability to dive safely. Many of the newer prescription medications do not have this side effect.

Safe for diving? Yes, but ... Avoid any antihistamine that makes you drowsy. As these drugs are frequently found in cold and sinus pills, read package labels carefully before taking.

Common brand names: Benadryl, Claritin, Zyrtec.

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Pain relievers

What are they? Most pain relievers act by preventing the body's normal inflammatory response to injury or illness. Aspirin, acetaminophen (Tylenol), ibuprofen (Advil, Motrin) and naproxen sodium (Aleve), are all examples. Prescription pain relievers, including ketoprofen (Orudis) and tramadol (Ultram), also fall into this category.

Prescription strength doses of Tylenol and ibuprofen are frequently combined with a narcotic for more powerful pain relief. Common combinations are acetaminophen/codeine (Tylenol #3), ibuprofen/hydrocodone (Vicoprofen) and acetaminophen/oxycodone (Percocet).

Potential downside: Any of the pain relievers that contain narcotics can cause drowsiness and impair judgment, especially if combined with alcohol.

Safe for diving? Yes, but ... Any over-the-counter pain reliever sold in the United States can safely be used while diving. However, pain reliever and narcotic combinations are sold over-the-counter in many other countries, including Canada. Check the ingredients carefully before taking any pain relieving medication purchased while traveling.

Common brand names: Tylenol, Advil, Motrin, Aleve.

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Seasickness Medications

What are they? Motion sickness medications are a class of drugs with which many divers are familiar. Common formulations include dimenhydrinate (Dramamine) and meclizine (Bonine). The primary prescription-only medication that is used for seasickness is the scopolamine patch (Transderm Scop).

Potential downside: Chemically related to antihistamines, seasickness medications can make you drowsy. While this may be just the thing for a long crossing, it can be dangerous while diving. Another common side effect is dry mouth, which can be aggravated by sucking on a regulator all day.

Safe for diving? Yes. Try different medications to identify which one causes the least drowsiness. Staying very well-hydrated and sucking on a candy or cough drop can help relieve dry mouth.

Common brand names: Dramamine, Bonine, Transderm Scop.

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Antidepressants and Other Psychiatric Medications

What are they? Over the last decade, antidepressants have become some of the most widely prescribed drugs among otherwise healthy people. The most common class of these drugs are Serotonin Selective Re-uptake Inhibitors (SSRIs). These drugs include fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft), among others. Also commonly used are an older class of medications called tricyclic anti-depressants, which includes such medicines as nortriptyline (Pamelor) and amitriptyline (Elavil). Many other anti-depressants are also available, and more come on the market each year.

Potential downside: The effects of pressure and depth on these medications has not been clinically studied, but any drug that affects the brain is a potential problem when combined with nitrogen narcosis. There is also the question of the depression itself. Each year, there are a small number of diving deaths suspected to be suicides. This has the potential to endanger others on the boat if a rescue attempt is made.

Safe for diving? No. While many people on antidepressants may be able to dive perfectly safely, the potential risks are significant and should be discussed with your physician and psychiatric caregiver. In most cases, however, the underlying psychiatric disorder will preclude diving.

Common brand names: Prozac, Paxil, Zoloft.

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Antibiotics

What are they? Antibiotics fight bacterial infection and are prescribed for a variety of conditions from urinary tract infection to pneumonia. There are hundreds of different antibiotics available today. Almost all of them are available only by prescription in the United States, but may be sold over-the-counter in other countries. Other medications that divers may be taking include those that treat fungal or yeast infections, and anti-virus medications such as those used to treat herpes or HIV.

Also in this class are drugs taken to prevent illness while traveling, such as mefloquine (Lariam), chloroquine (Aralen) and doxycycline for malaria.

Potential downside: Side effects of these drugs can include nausea or diarrhea, which can lead to dehydration, increased skin sensitivity to the sun, and particularly in the case of mefloquine, psychiatric changes. There are also the risks posed by the infection for which you are taking the drugs in the first place. Pneumonia or bronchitis can interfere with breathing, while diarrhea can contribute to dehydration, which increases the risk of getting bent.

Safe for diving? Yes, usually. Most antibiotics can be taken safely while diving. If the illness they were prescribed for doesn't prevent you from diving, then it's unlikely that the medication will.

Divers should be aware of potential side effects of antibiotics. Some, such as doxycycline, can make you sensitive to sunburn. Metronidazole (Flagyl) will make a person incredibly sick if they drink alcohol, and drugs such as erythromycin can cause an upset stomach. Have your doctor choose an antibiotic with the most manageable side effects.

Your options are limited when it comes to anti-malarial drugs. In parts of the world, malaria parasites are resistant to chloroquine, so doxycyline or mefloquine will be required. The psychiatric side effects of mefloquine, and the lack of information about how depth might make this worse, make doxycycline the drug of choice for divers--just use a high-SPF sunscreen.

Common brand names: Zithromax, Lariam, Aralen.

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Diarrhea and heartburn medicines

What are they? Medications to control the pain and burning of gastritis--commonly called heartburn--are among the most commonly prescribed medications in the United States. These include prescription-only drugs like omeprazole (Prilosec) and lansoprozole, and medicines like ranitidine (Zantac), cimetidine (Tagamet) and famotidine (Pepcid), which are available over-the-counter.

Another stomach problem that is likely to be encountered by divers is diarrhea. The medicines most often used to relieve this unpleasant condition include bismuth preparations (Pepto-Bismol), loperamide (Imodium) and diphenoxylate (Lomotil).

Potential downside: Assuming you stay well-hydrated, neither the condition or these drugs are likely to be dangerous. Lomotil is a narcotic drug related to codeine, and can make you sleepy, and some drugs--notably Zantac--have been reported to make users drowsy.

Safe for diving? Yes. The low incidence of side effects makes these medications generally safe for diving. The one exception is Lomotil, a narcotic drug that should be avoided.

Common brand names: Imodium, Pepto-Bismol, Prilosec, Zantac.

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Asthma medications

What are they? Common drugs to treat asthma include steroids, beta-agonists, and drugs that interrupt the chain of events that can precipitate an attack. Steroids, which reduce inflammation in the airways of the lung, can be taken either as prednisone pills or via an inhaler. There are currently many different inhaled steroid preparations on the market, including brand names such as Flonase, Vancenase, Azmacort and AeroBid. Beta-agonists cause the muscles of the airway to relax and are usually delivered to the lungs via an inhaler. The most commonly used beta-agonists are albuterol (Proventil, Ventolin), pirbuterol (Maxair) and salmeterol (Serevent). Other medications that are commonly used by people with asthma include ipatropium bromide (Atrovent), zafirkulast (Accolate), cromolyn sodium (Intal) and theophylline (Slo-Bid, Theo-Dur, Uniphyl).

Potential downside: While some beta-agonists can cause the heart to race, most of these drugs have minimal side effects. The greater danger is the asthma itself. An attack while diving could lead to air becoming trapped in the lungs and arterial gas embolism (AGE) while ascending. The sensation of being unable to catch one's breath can also trigger panic under water.

Safe for diving? Maybe. While the drugs are not generally a problem, the underlying condition can be. Until five years ago, all asthma was an automatic disqualifier for diving. Today, cases triggered by exercise or cold are still considered a contraindication to diving, but sufferers of most other kinds of asthma can dive as long as their condition is well-controlled. Consult your doctor, and the Divers Alert Network (DAN).

Common brand names: Flonase, Azmacort, Proventil, Serevent.

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Herbal Remedies, Vitamins and Dietary Supplements

What are they? Alternative medications and dietary supplements such as vitamins, herbal cures, and medicines like melatonin are becoming increasingly popular in the treatment of conditions ranging from sleeplessness to cancer.

Potential downside: Since these medicines and supplements are loosely regulated, you can't always be sure what's in them. In New York City, for example, a popular Chinese "herbal" remedy for stress was found to contain large amounts of Valium. On a more mundane level, drugs like Melatonin can cause drowsiness.

Safe for diving? Yes. For the most part these vitamins and medicines are safe to use while diving. Stick with products from a reputable manufacturer, and avoid anything that makes you feel tired or jumpy. If you are taking herbal remedies with any prescribed drugs, clear their use while diving with your doctor since there can be dangerous interactions.

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Contraceptives and Viagra

What are they? Birth control pills are composed of progesterone, often combined with estrogen. The pill essentially fools a woman's body into thinking it is pregnant so that an egg is not released during the menstrual cycle. Viagra, initially developed as a blood pressure medicine, is the first male impotence drug on the market.

Potential downside: Any medicine that has estrogen can increase a woman's risk of developing blood clots in the legs. This is particularly likely during long periods of inactivity, like plane flights. Viagra has few side effects other than lowering blood pressure.

Safe for diving? Yes. There is little risk to diving while taking birth control pills. But if you are going to use Viagra, I would recommend skipping the night dive.

 

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