Dr. Sebastiano
Venturi
investigator on Iodine Deficiency Disorders
and Iodine metabolism
|
-Iodine in biology |
Dr. Sebastiano Venturi C.V. |
 |
"Dietary Iodine and Gastric cancer"
Sebastiano Venturi and Coll.: M. Venturi, A. Guidi, F.M. Donati
Project of study published in "Directory of on-going research in cancer epidemiology" 1994 and 1996, IARC books, Lyon
The aim of this study is to test the hypothesis
that iodine deficiency, or, in some cases, iodine excess is a risk factor
for gastric cancer. Recent regional and district data on the epidemiology
of endemic goitre and gastric cancer in Italy will be correlatad. Gastric
cancer trends (until 1997) will be monitored in the populations (district
of Montefeltro, Bolzano and Garfagnana) where iodine prophilaxis have
been introduced only in recent years (1981-1985). Atrophic gastritis prevalence
in Montefeltro district will be reconsidered, and gastric cancer mortality
trends in the province of Aosta, where the iodine prophilaxis was interrupted
in 1975, will be analysed. The iodide-trapping ability of the stomach
and the thyroid gland is inhibited by goitrogens, such as nitrate, thiocyanate
and salt, previously studied as risk factors for gastric cancer. Previous
studies have shown that iodine deficient individuals have more gastric
cancer and atrophic gastritis than non deficient subjects; it is believed
that iodine is able to regulate gastric trophism and antagonise the action
of the above mentioned iodine inhibitors.
A paper was published in Eur. J. Cancer Prev., 2:17-23, 1993
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