Brain
Inj 2001 Oct;15(10):879-89
Amnesia,
neuroendocrine levels and PTSD in motor vehicle
accident victims.
Flesher MR,
Delahanty DL, Raimonde AJ, Spoonster E.
Kent
State University, Kent, OH 44242, USA.
PRIMARY OBJECTIVE: To examine the initial
neuroendocrine responses and subsequent PTSD
symptomatology among amnesic and non-amnesic
victims of motor vehicle accidents. It was
hypothesized that amnesic patients would be less
likely to meet PTSD criteria at 1 month follow-up
and would display lower catechalomine levels and
higher basal cortisol than non-amnesics. METHODS
AND PROCEDURE: Fifteen-hour urinary hormone
samples were collected from 70 MVA victims upon
hospital admission. Participants were assessed for
PTSD symptomatology 1 month later. Main outcomes
and results: Amnesic patients displayed lower NE/cortisol
ratios than non-amnesics, were less likely than
non-amnesics to develop PTSD, and displayed fewer
PTSD symptoms than non-amnesics. CONCLUSIONS:
Amnesics may physiologically experience a motor
vehicle accident differently from non-amnesics and
have lower subsequent PTSD incidence. These
results provide partial support for the hypothesis
that amnesia for a traumatic event can serve as a
buffering function in the development of
subsequent PTSD among MVA victims.
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