Pistoia 118

Sala lettura

Direttore DEU Dr.ssa Ione Niccolai
Direttore Centrale Operativa
118 Dr. Piero Paolini
Viceresponsabile 118 Dr. Luca Rosso
Capo sala 118 Lori Cecchi



Z Rheumatol 2001 Dec;60(6):416-24

Peripheral analgesic and antiinflammatory effects of opioids.

Stein C, Machelska H, Schafer M

Department of Anesthesiology and Critical Care Medicine, Klinikum Benjamin Franklin Freie Universitat Berlin Hindenburgdamm 30, 12000 Berlin, Germany. cstein@medizin.fu-berlin.de

[Medline record in process]

Traditionally, opioids were considered the prototype of centrally acting analgesics. In the past decade a substantial literature has emerged demonstrating that opioids can produce potent and clinically measurable analgesia by activation of opioid receptors on peripheral terminals of primary sensory neurons. In addition, endogenous ligands of these peripheral receptors were discovered in immune cells. Major recent findings in peripheral opioid analgesia include the relative lack of tolerance under inflammatory conditions, tetrapeptides as novel peripherally restricted compounds, the potent antiinflammatory activity of mu- and kappa-agonists and the identification of selectins as important molecules governing the homing of opioid cells to injured tissue. In addition to the extensively documented efficacy of locally applied morphine in post-surgical pain, clinical studies have now moved into the field of chronic arthritic pain.



Pistoia emergenza 118 - site 2002 -