Curriculum Vitae of Dr. Luciano Vittozzi
(Selected activities)

University degree: Laurea (M. Sc.) in Chemistry (organic-biologic branch) cum laude - University of Rome, 1973


Current Position
? Since 1982: in charge of the Direction of the Biochemical Toxicology Section of the Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanità
? Since 1990: achieved the position of ?Research director? at Istituto Superiore di Sanità
Professional Expertise                            Publications

Research Activity and Scientific Production
The research activity of dr. L. Vittozzi developed initially in the Biological Chemistry Laboratory of ISS with studies of the genetics and enzymology of wheat seed proteins. When dr. Vittozzi joined the newly established Toxicology Department of ISS, his studies were addressed to the characterisation of xenobiotics-metabolizing enzymes in mammals and fish; subsequently he dealt with the metabolism and mechanisms of toxicity of chloroform (as a model of non-genotoxic carcinogenic halogenated hydrocarbons) in mammals and human tissues and of organophosphate pesticides in fish. More recently, the experimental activity of dr. Vittozzi has been also devoted to the applications of mechanistic/metabolic studies to risk assessment, including species- and dose-extrapolations as well as individual susceptibility factors with both organophosphate pesticides and chloroform. Such activity involved both in vitro and in vivo studies.

The scientific production can be summarized as follows:

  • 52 publications on International peer-reviewed journals
  • 1 IPCS (WHO) Monograph (Co-author and Vice-chairman of the Working Group) (1992)
  • A prototype of a Database on the toxicological and environmental properties of pesticides (PESTINFO)
  • 10 publications on National journals
  • 1 Book (in Italian)

    • Professional Expertise
    Participation of dr. Vittozzi in National and International Committees and Scientific Organisations dates back to 1981; since 1986 such activity  has become more and more predominant over experimental research. Major aspects of such activity were:
    ? participation in several International (and National) Committees, aimed at
    ? the toxicological assessment of different kinds of chemicals
    ? updating guidelines for toxicity and ecotoxicity testing, and setting strategies for the classification of chemicals and for environmental risk assessment;
    ? funding research projects and fellowships in toxicology and ecotoxicology;
    ? participation in networks for the design and implementation of toxicological and ecotoxicological databases on chemically-defined flavourings (EU Network), food plant toxicants (EU Network), and pesticides (National project).
    ? Inspections to Toxicology Testing Laboratories aimed to the EU-recognized Certification of compliance to the OECD Principles of Good Laboratory Practice (for the International acceptance of toxicity test results)

    National Committees

    Italy
    - Member of the National Committee for Pesticide Products (1996-  )
    - Expert for the National Toxicology Committee (1988-1997).
    - Member of the National Inspector Group for Good  Laboratory Practices (1994- ).
    - Member of the Working Group for the Risk Assessment of Existing Chemical Substances (1998- )
    Germany
    - Expert for a Committee of the German Ministry of Education, Science, Research and Technology for funding of a research project  (Foerderschwerpunkt ?Oekotoxicologie?) (1994 and 1997)
    European Union
    - Expert of the committee for the evaluation of research projects submitted for the STEP programme (1990)
    - Expert  for  the EEC Ad Hoc Committee for the  Classification  of Substances as Ecotoxic (1988-1990)
    - Member of the EEC Committee on Testing Strategies for the Assessment of Ecotoxicological Risk (1993-1994)

    OECD
    - National Delegate in the Updating Panel of OECD Toxicological Test Guidelines for the review of several  guidelines (mammalian metabolism and  toxicokinetics; sensitization; fish acute and prolonged toxicity;  bioconcentration  in fish) (1981-1987).
    - National Expert for the  OECD Test Guidelines Programme - Environmental and Health Effects (1995-)

    WHO
    -Vice-chairman of the IPCS Working Group for the assessment of the Environmental Health Criteria and Safety Data Sheet on Chloroform

    ESF (European  Science Foundation)
    - Member of the ESF EERO (European Environmental Research) Standing Committee (subcommittee of the Life and Environmental Science Committee) (1996- )
    - Chairman of the ESF Steering Committee for  Research  Fellowships  in  Toxicology  and Ecotoxicology (PFT) (1991-1995).

    EERO (European Environmental Research Organization)
    - Member of the Executive Committee (1994-96)


    Other Activities
  • Member of the Editorial Board of a few Journals devoted to Toxicology and Environmental Toxicology.
  • Organization of several National and International Symposia including:
  •     IV European ISSX Meeting "Toxicological Evaluation of Chemical interactions: Relevance of Social, Environmental, and Occupational Factors" - Bologna July 3-6, 1992 (Chairman of the Organizing Committee).
  •     SECOTOX  Regional Meeting: Environmental  Toxicology:  Hazards to Environment and Man in the Mediterranean Region - Roma, September 27-30, 1993 (Chairman of the Organizing Committe).
  •     MDO2000 13th International Symposium on Microsomes and Drug Oxidations, Stresa (Italy) July 10-14, 2000 (Member of the Organizing Committee)
  • Co-director of the ETAF International Course on "General Toxicology", Wageningen (NL) November 1999
  • Charges in some scientific Societies, such as:
  •     Vice-President of the Italian Society of Toxicology (1996-2000).
  •     Member of the Executive Board of SECOTOX (International Society of Ecotoxicology and Environmental Safety) (1996-2000)
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