Medicated Uterine Infusions as a Means of Achieving Higher
Rates of Conception
-- Gabriella Bozzini --
In 1995, when I started my alpaca breeding program, I read as much of the literature on
the subject as I could find. Most of the information that I found dealt with the problems
a breeder might have to face in times of difficult births or weak crias. The breeding and
achievement of conception actually all seemed to be pretty straightforward: the pair
breeds, after 335-350 days of gestation a cria is born, and 14 days after parturition the
female becomes receptive once again to breeding thereby starting the cycle all over
again.
That easy, right? Wrong! At least, this wasnt my experience in the
beginning.
Since 1995, I have had 23 farm
births. Only one was a dystocia that required veterinary assistance, and two others were assisted births that required minor
intervention. The
birthing experience has been the most exciting and rewarding part of the breeding program
whereas the achievement of pregnancy has been the most anxiety-ridden.
1995 and 1996 were my most troubling years as I would see my females giving birth to
beautiful, healthy crias and then breeding repeatedly afterwards without achieving
conception. Some females would breed in excess of 15 times; some would breed, spit off the
male for a month or two and then become receptive again.
At first I thought that perhaps my inexperience was somehow to fault. Perhaps I was doing
something wrong? I researched the subject but found little help in the published
literature and talks with my vet and physical exams revealed no reproductive tract
deformities or reasons for induced infertility. However, in talking of my concerns to
others in the industry, I realized that I was not alone in facing these types of
reproductive problems.
Finally, in my own files, I found a paper by Edna
Kennedy, a breeder from New Mexico who
is no longer in business, that was given to me upon the purchase of two of her
girls. She
had had similar problems and had tackled it by giving her alpacas uterine
lavages. She
notes in her short paper that "there is evidence to suggest that low grade,
asymptomatic uterine infections are the major cause of idiopathic breeding problems in
female Camelids. Thats why flushing (...) once a day for three days, (...)
tends to
eliminate these types of covert uterine infections, (and) also tends to resolve most
unexplained breeding problems."1
I shared this paper with my veterinarian and, with his assistance, began treating my
"problem females" in 1996. For the first three days post-partum, the alpacas
received a uterine infusion along with an antibiotic treatment. The results were
astounding. The first five females that received this treatment bred only once on the
fourteenth day after birthing, and they all achieved and maintained their
pregnancies.
These are the same alpacas that had previously required repeated breedings over a period
of several months.
My veterinarian explained that this procedure would be most effective only if performed
during the immediate post-partum period when the cervix is most dilated. It is during
these early days that a flush can more easily reach the uterine cavity and treat any
possible low-grade infections caused by the birthing trauma. Performing the lavage any
time after this, would at the very least, be ineffective and, at the very worst, actually
introduce harmful bacteria into the reproductive tract of the alpacas.
The breeding season of 1997 has been the most successful yet as Ive begun using this
uterine flush and antibiotic treatment systematically with all my breeding
females. This
prophylactic measure has been included in my management program so that all
mothers,
experienced as well as first-timers, receive the treatment regardless of their respective
birthing experience. The result has been remarkable: This year, all my female alpacas got
pregnant upon their first and only exposure to my stud. They have also all maintained
their pregnancies beyond the third month of gestation without any further
complications.
While my small group of females and my limited experimentation does not provide conclusive
data, it does suggest that this benign and inexpensive post-partum treatment might be
quite helpful in aiding females heal and treat their reproductive tracts after
birthing.
If you have had similar reproductive problems with your alpacas and would like to receive
a free pamphlet that describes how to perform the procedure and what supplies and
materials are required, please contact me. Your responses will be recorded and eventually
mailed to AOBA. Hopefully the results from this informal collection of breeders
responses will provide more impetus to the industry to fund further research not only in
reproductive pathologies but also in the value of employing this prophylactic
measure.
_________________
1. Edna Kennedy: "Medicated Uterine Infusion as an Adjunct to Successful
Breeding."
Uterine Lavage for Camelid Breeding Management
-- Ky Dehlinger DVM --
Intrauterine lavage has been used in various species for the treatment of reproductive
failure due to intrauterine infections, both chronic and acute, and for the abnormal
accumulation of intrauterine fluid. The most common species that we see this in, is the
equine. Various therapies have been proposed in the medical literature: intrauterine
antibiotics, oxytocin infusion, prostaglandin F2a, and large volume uterine lavage
(see
American Journal of Veterinary Research, Vol 56, No.4, April 1995, p.468-472). The first
aspect of a good reproductive examination in mares which are failing to come into foal
involves ultrasonography which may show intrauterine cysts, intrauterine fluid, or no
changes at all. Often, horse owners will elect intrauterine cultures and sensitivities for
problem breeders; hystopathology on uterine biopsies will show normal endometrium
(Kenney
category 1) to severe endometrial changes (Kenney category 3). We begin intrauterine
infusions with isotonic, sterile fluids and evacuating that fluid as a treatment for the
mares that are not getting bred: sometimes oxytocin is concurrently given (20 IU
intravenously or intramuscularly) to promote uterine contractions for the evacuation of
the fluid. Unfortunately, in camelids, it is difficult to evaluate intrauterine
pathology.
Based on our successful treatment of mares, we modified our treatment recommendations
for post-delivery camelid dams who were not breeding back successfully. It was assumed
that at delivery, possible vaginal and subsequent uterine low grade infections were
occurring. Due to the difficulty of uterine examination and intrauterine treatments in
camelids, this treatment is done following delivery by taking advantage of a dilated
cervix. Moreover, this is not an easy species to examine and do routine reproductive
diagnostic procedures. Thus, a prophylactic treatment following delivery is recommended to
owners of alpacas and llamas. An intravaginal infusion with a 5% betadine solution is
recommended post-delivery; we speculate that this stimulates endogenous prostaglandin
release. At the same time, we recommend systemic antibiotics for 3 days; some papers have
suggested the use of intrauterine antibiotics or antibiotics in the lavage. Some reports
in the bovine literature however suggest that intrauterine antibiotics can reduce
fertility and we therefore avoid using intrauterine antibiotics in most cases. This
treatment is considered prophylactic and is performed by the owner. Since initiating this
protocol, there has been good success at breeding back female camelids.
____________
Ky Dehlinger is a veterinarian at:
Valley Veterinary Clinic - Large & Small Animal Practice
Rt. 11, Box 210 DDD - Santa
Fe, New Mexico 87501
(505)455-2228 fax (505) 455-7292
Supplies & Procedure for Alpaca Uterine Infusion